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　　Kyohei Aizawa, an assassin for a covert non-governmental espionage group in Japan called "SEEK", is grieving over the loss of his girlfriend from a tragic plane accident. The leader of "SEEK",Ryo Mikumo, contacts him for an emergency mission; save a fellow agent, recover a new highly explosive liquid called "RDX@", stop a ruthless Yakuza leader, Sojiro Kotsuki, and his gang before they take over Japan. Although the Ninjas were thought to have disappeared... the new breed of assassins live on helping to protect Japan and all that is right; the Ninjas are coming soon.

2025年，在鹿儿岛县与冲绳县，搭载着配备手术室的特种车辆的渡轮已开始进行试运行。赴任的喜多见与夏梅在离岛从事医疗工作。某日，鹿儿岛县的诹访之濑岛发生火山喷发，为营救岛民，他们毅然挑战这项九死一生的任务。